#154: ⚙️ Are You Ready For a 100-Year Life?
My Longevity Economy Wheel Framework Shows You What You Need
Hey Friends,
Last week I attended the NEXii Longevity Congress, where we discussed all things longevity, including the economy, community, biotech and wellness.
I appreciated that the meeting was a gathering of people who address many different aspects of longevity, including policy, community and our minds and bodies.
I’ve been thinking about how longevity extends far beyond just the biology of extending aging, and over the last week I’ve been thinking about how to frame it.
I actually drew out a sketch in my notebook a couple weeks ago and shared it with some of the conference attendees at lunch.
When they pulled out their phones to take a photo of my sketch, I knew it needed to be shared.
I’m calling this new framework the Longevity Economy Wheel.
Let’s go.
P.S. I published this newsletter on YouTube here:
💬 In this note:
⚙️ Are You Ready For a 100-Year Life?
📚 Lex Fridman Episode #481
⚡️ 106-Year Old Balinese Dancer
#154: ⚙️ Are You Ready For a 100-Year Life?
For the past few months, I’ve been wrestling with a problem.
Everyone talks about “longevity” like it’s just another word for health and wellness.
Fancy supplements. Biohacking clinics. Wearables.
This is all a great start, but longevity is so much bigger than that.
If we’re going to live to 100, we need more than optimized bloodwork.
We need careers that span 60+ years.
Financial systems that don’t collapse at retirement.
Communities designed for multi-generational living.
Purpose in life that extends beyond our working years.
In July 2025, in Nina’s Notes #139, I wrote about where I would invest in longevity.
I said I’d place bets on companies working on:
Small Molecule Lifespan Extension Drugs
Elderly Care
Financial Planning / Future of (Elderly) Work / Lifelong Learning
Next-Gen At-Home Diagnostics
Psychedelics For Trauma + Aging-Related Cognition
AI-Driven Personalization of Health Protocols
Social Tech That Reduces Isolation
Neurotech For Performance and Prevention
These are topics that span a variety of industries.
If you want to get granular, it is Pharma, AgeTech, EdTech, Diagnostics, BioTech and NeuroTech.
Is all of that “longevity?”
In my opinion, yes.
Longevity science asks: How do we slow, prevent, or reverse biological aging?
AgeTech asks: How do we design technology so people can live longer, healthier, more independent lives?
Elderly Care Tech asks: How can we age well, in place?
All are fighting the same enemy: aging, and with it the decline in physical, cognitive, and social function.
Right now, Longevity and Wellness are becoming synonymous.
But I think this dilutes the impact that the longevity economy can make.
Longevity covers literally everything. Every aspect of our lives.
So I built a framework to make sense of it all.
Longevity Economy Wheel
© Nina’s Notes 2025
I’m breaking longevity down into four overarching categories and 12 specialized sectors.
Categories:
Science
Lifestyle
Business
Society
Within the four categories, we have specializations of different industries that will address the needs of the longevity economy.
All the specialized sectors of the Longevity Economy fit together like spokes into a wheel.
Each wedge needs the others to move the longevity economy forward so that we can all live long, prosperous lives.
For example, we have Longevity Biotech (LongBio), a term coined years ago by Sebastian Brunemeier.
LongBio refers to “an emerging subfield of biotechnology focussed on the development of therapies that target the cellular and molecular processes of aging in order to extend healthy human lifespan.”
LongBio is now a common term in the industry.
Following along with that naming convention, I’m coining 10 new names for industries in the Longevity Economy Wheel.
Science
Longevity Technology (LongTech)
Longevity Healthcare (LongCare)
Longevity Biology (LongBio)
Lifestyle
Longevity Wellness (LongWell)
AgeTech
Longevity Built Environments & Community (LongHome)
Longevity Tourism (LongTour)
Business
Longevity Finance (LongFin)
Longevity of Business (LongBiz)
Society
Longevity Policy / Governance (LongGov)
Longevity Education (LongEd)
Longevity Purpose (LongSoul)
In my guidebook, you will get a full explanation of the Longevity Economy Wheel framework that maps the entire ecosystem with real companies, specific examples, and clear definitions for each sector.
Why This Matters
If you’re building in longevity, this framework will help you understand where your work fits in the bigger picture. This will help to identify collaboration opportunities across sectors, spot gaps and opportunities in the market and communicate your impact more clearly.
If you’re investing in longevity, this will help you see the full scope of opportunities beyond just biotech, understand how different sectors interconnect, and build a more diversified longevity portfolio
If you’re just longevity-curious, this will help you make sense of a complex, rapidly evolving field, understand how different innovations work together and see where you can make the biggest impact for your personal health, and long life.
Get The Full Guidebook
This framework is too comprehensive for a single newsletter (trust me, I tried).
So I’ve turned it into a complete guidebook with:
Detailed breakdowns of all 12 sectors
Real company examples in each category
Key players and thought leaders
Investment themes and opportunities
How each sector interconnects with the others
Download the Longevity Economy Wheel Guidebook from my website
Lucky for us entrepreneurs, that means endless opportunities to build and impact longevity.
If you’re building in one of these sectors, I want to hear from you.
Tell me what you’re working on in the comments or via DM!
Want to go beyond the newsletter?
I can help you apply this framework to your business or investment thesis.
I mentor founders, advise VC funds and help ambitious professionals take their businesses and personal health to the next level.
Click here to learn more about private mentorship and upcoming group sessions here.
🎧 Content of the Week
Episode #481 - Norma Ohler: Hitler, Nazis, Drugs, WW2, Blitzkrieg, LSD, MKUltra & CIA on the Lex Fridman Podcast
Rating: ★★★★★
In this episode Lex interviews Norman Ohler, a historian and author of the book “Blitzed: Drugs in the Third Reich.” He is currently working on a new book with the working title “Stoned Sapiens.” (Can’t wait for that one!)
I was hooked within the first 5 minutes of the episode, as Norman describes two groups in the 1930s, the “drunks in Munich” and the “drug-users” in Berlin.
The two groups behave completely differently. One, fueled by alcohol, adopting a combative attitude and the idea of “us vs. them,” and the other, high on drugs, mistrusting of the government and rebellious. (This reminded me of Nina’s Notes #55: Alcohol vs. Psychedelics, where I discuss the difference in personalities of the people at a party under the influence).
Quickly in the episode, I learned that from 1920-1923 the Bürgerbräukeller was one of the main gathering places of the Nazi Party.
That was where, on 8 November 1923, Adolf Hitler launched the Beer Hall Putsch.
This was Hitler’s first failed attempt to overtake the government, which resulted in Hilter being shot in the stomach, starting his addiction to morphine.
The rest of the episode discusses how methamphetamines were used as a performance enhancing drug by the German military, the isolation of morphine from opium by a German chemist, and ultimately Hilter’s dependency on morphine.
Definitely give it a listen. It’s a long episode (4.5 hours), but at 1.5-2x speed, you can get through it a lot quicker and the pace isn’t too fast.
I really loved this episode because in the early days of Nina’s Notes, in edition #27, I wrote a short form article about the use of drugs and psychedelics by the CIA referencing the MK-Ultra program in the 1950s-1970s (Check it out here: #27: The Dark Side of Early Psychedelic Research: Unethical Practices and Discrimination).
And it really just makes so much sense….Blitzkrieg would not have been possible without methamphetamine.
⚡️ Check This Out
Niang Soli is a 106-year-old Legong dancer.
She was caught on film and video by photographer @taniachatterjee.official
Her dancing circulated the internet on instagram.
We see her moving with grace, precision and magic.
I truly believe that dance is medicine - read more about it in Nina’s Notes #114 - Dance for Better Brain Health. I also talk about dance as medicine and how I incorporate dance into my life in Nina’s Notes #126: My 6 Pillars of Longevity.
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Edited by Wright Time Publishing
Very useful framework thanks so much for creating it! As someone interested but not actively in the longevity space I often get a bit lost with all the different areas in this space :)